It is no surprise that spaceflight is inherently dangerous - with ample studies demonstrating how microgravity causes bone loss and muscle atrophy among many other morbidities. However, this research was carried out predominantly on men - so, the effect of spaceflight on women is not really known. On top of all the risks that spaceflight poses, female astronauts are commonly encouraged to take the contraceptive pill to prevent pregnancy and for hygiene reasons. As the pill has some well known negative side effects on Earth dwellers - this would logically translate to space-faring astronauts. However, we found our that - not only does the pill cause additional side effects in space such as depression it overlaps with and compounds other effects like exacerbating the risk of developing certain cancers. So, you may be asking yourself - why do the astronauts continue taking the pill in space? Well, because there is no current research (until now) available that discusses the effects of the pill in space.